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Pernicious anemia The pathophysiology of AIG has not been clearly defined but is associated with: [2] [6] [7] Antiparietal cell antibodies: target gastric parietal cells → ↓ acid production and atrophic gastritis and ↓ intrinsic factor production → ↓ vitamin B 12 absorption in terminal ileum [2] [7] Autoreactive T cells target gastric proton pump (H+/K+ ATPase) and are likely the main mediators of inflammation in AIG

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1 RCTs are widely regarded as the best research design for evaluating the impact of clinical interventions on patient outcomes